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ea0011p681 | Reproduction | ECE2006

Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males

Dhillo WS , Chaudhri OB , Patterson M , Thompson EL , Murphy KG , Badman MK , McGowan BM , Amber V , Patel S , Ghatei MA , Bloom SR

Mutation of the GPR54 receptor is associated with a failure of reproductive function. The endogenous neuropeptide agonist for GPR54, kisspeptin, potently stimulates the hypothalamic-pituitary-gonadal (HPG) axis in rodents and primates.Objective: The present study was designed to determine the effects of elevating circulating kisspeptin levels on LH, FSH and testosterone in male volunteers.Method: Study (i) Volunteers were infused w...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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